
Alpha-lipoic acid is an antioxidant known for its potential to support weight loss and lower blood sugar levels, particularly in people with diabetes. Research is ongoing, and the benefits and side effects are important to understand.
Health Conditions
Many integrative medicine providers believe ALA may help prevent or manage health conditions like high blood pressure. Research primarily focuses on its role in managing diabetes and aiding weight loss.
However, alpha-lipoic acid has been studied for benefits with health conditions such as:
- Liver disease
- Polycystic ovarian syndrome (PCOS)/polyendocrine metabolic ovarian syndrome (PMOS) and infertility problems
- Cancers, including breast and colon cancers
- Brain injury due to stroke
- Neurodegenerative diseases, like Parkinson’s and Alzheimer’s disease
- Chronic kidney disease
- Infections, including yeast infections, COVID-19, and Rocky Mountain spotted fever
- Anti-aging and inflammation effects
- Rheumatoid arthritis, lupus, and other autoimmune diseases
- Erectile dysfunction
- Nerve function
To date, there is little evidence to support any of these claims for ALA use. Keep in mind that no supplement is intended to treat, cure, or prevent disease.
May Help With Weight Loss
Research on ALA for weight loss is still preliminary and lacks firm conclusions. Studies have shown:
- A 2017 review of studies found that ALA supplements, ranging in doses from 300 milligrams to 1,800 milligrams daily, helped prompt an average weight loss of 2.8 pounds compared to a placebo.
- A 2018 review similarly found that ALA resulted in more weight loss compared to placebo. However, the average weight loss was only 1.5 pounds.
- In 2020, a meta-analysis found that treatment with ALA significantly reduced body mass index (BMI) and reduced weight by about 5 pounds as compared to a placebo. BMI is an estimate of body fat based on height and weight.
While these three systematic reviews offer some promising evidence, the study methods varied greatly among the individual studies, and the amount of weight loss was small. As a result, it’s difficult to draw firm conclusions from them.
May Help Control Blood Sugar
ALA might help control glucose by enhancing blood sugar metabolism, potentially aiding diabetes management. The research results, however, are mixed and include:
- A 2018 review of 20 randomized controlled trials looked at ALA use in people with metabolic disorders, including type 2 diabetes. Results showed ALA supplements lowered fasting blood glucose, insulin concentration, insulin resistance, and hemoglobin A1C levels. Your hemoglobin A1C level shows your average blood sugar over the past three months.
- A 2019 review suggested that ALA reduced fasting blood glucose and A1C levels.
- A 2021 review found that ALA supplementation reduced insulin and insulin resistance but did not reduce A1C levels.
If you have diabetes and are considering ALA supplementation, ask a healthcare provider if it would be appropriate for your needs.
May Help With Neuropathy
ALA is an antioxidant that acts to limit cell damage from harmful compounds called free radicals. The antioxidant properties may help with neuropathy, which causes symptoms like nerve pain, numbness, and tingling.
An analysis of five studies found ALA helped improve function and reduce pain after surgery for people with carpal tunnel syndrome—a condition in which compression of a nerve in the wrist produces tingling, numbness, weakness, and pain in the hand and fingers.
Neuropathic pain is the medical term used to describe the pain, numbness, and abnormal sensations caused by nerve damage. The damage is often caused by oxidative stress placed on the nerves by a chronic disease, such as:
- Diabetes (diabetic neuropathy is a common complication)
- HIV
- Kidney failure
- Lyme disease
- Shingles
- Thyroid disease
A 2021 study found that people with pain from unknown causes reported less severe pain scores when they took between 400 milligrams and 800 milligrams of an oral ALA supplement compared to those who took a placebo.
A review of studies concluded that the antioxidant properties of alpha lipoic acid could help manage neuropathic pain, though it also noted that clinical studies have been inconsistent with dosing and treatment protocols. And because ALA is often combined with other compounds, it’s not yet known how much benefit is due to ALA.
May Reduce Heart Disease Risk Factors
A 2018 study suggested ALA may improve lipids, including “bad” low-density lipoprotein (LDL) cholesterol and triglycerides, but found no improvement in “good” high-density lipoprotein (HDL) cholesterol.
However, results are mixed, with a 2019 study showing no improvements in blood lipid levels with ALA.
There is some evidence that ALA can reduce markers of inflammation, such as:
- C-reactive protein
- Interleukin-6
- Tumor necrosis factor-alpha, which promotes insulin resistance and is associated with type 2 diabetes
High levels of C-reactive protein are considered a risk factor for heart disease.
A 2019 review found a significant reduction in all three markers with supplementation of ALA.
Another study published in 2020 found that 600 milligrams of ALA given orally for four months significantly reduced these same inflammatory markers.
May Support Skin Health
ALA is an ingredient in many skin care products. In several small studies, ALA has been shown to reduce water loss from the skin and improve skin hydration, skin scaling, and roughness.
As an antioxidant, ALA may help protect against skin damage by protecting against the sun’s harmful UV radiation and reducing fine lines, wrinkles, and age spots.
However, some of these studies are older, and larger studies are needed to confirm whether ALA has these skin benefits.
Primary Mitochondrial Disorders
ALA supplementation has been recommended in people with primary mitochondrial disorders, or PMDs. PMDs are rare genetic disorders that occur due to errors in the function of the mitochondria, limiting the body’s ability to make energy within cells and leading to seizures and other symptoms.
Most of the evidence for ALA use is based on case reports, though, simply because the disorders are so rare. Research data are lacking, and people with PMDs should be monitored by a team of specialists who focus on these complex metabolic disorders.
Are There Side Effects Associated With ALA?
ALA is generally considered safe when taken as an oral supplement or used as a topical (cream) ointment. It also can be used intravenously. There do not appear to be significant adverse effects with ALA.
However, some people may experience side effects that include:
- Low blood sugar
- Nausea
- Rash (when using an ALA cream or ointment)
- Vomiting
- Headache
- Heartburn
Since ALA is an acid, it may contribute to reflux. Eating a small snack (like graham or saltine crackers) when taking a supplement can help ease heartburn or reflux.
Precautions
ALA is possibly safe in children aged 10-17 years when taken by mouth in doses up to 600 mg daily for 3 months. However, when taken in larger amounts, seizures, vomiting, and unconsciousness have been reported.
Like many other supplements, ALA is not recommended for people who are pregnant or breastfeeding. Not enough research has been done to understand ALA’s effects in these groups, although some studies suggest there may be benefits for people with complicated pregnancies.
Drug Interactions
ALA supplements may interact with:
- Thyroid medication
- Statin cholesterol drugs
- Chemotherapy treatment
- Diabetes medication
- Blood thinners
Sources and Dosage
The food you eat will always be your best source of nutrients. If you eat plenty of leafy green vegetables, seeds, and nuts, you may be able to get plenty of ALA from your diet. ALA can be found in:
- Kale, spinach, and other leafy greens
- Nuts and seeds (such as flaxseed, chia seeds, and walnuts)
- Plant oils (such as flaxseed oil, soybean oil, and canola oil)
- Oil-based salad dressings
ALA deficiency is extremely rare. Generally, healthy people can produce all the ALA the body needs. The recommended amount of ALA daily is 1.6 grams for men and 1.1 grams for women. There is also no set upper intake limit.
If you take too much ALA, you may experience side effects that typically resolve when the supplement is stopped. There are cases of severe symptoms from taking large amounts of ALA, including seizures and organ failure.
In one case, a 22-year-old woman experienced tachycardia (rapid heartbeat), altered mental state, and metabolic acidosis.
Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs.
Like most nutritional supplements, ALA should be stored in a cool, dry place.

























